Gene Synthesis Market By Products And Services (Consumables, Software’s, Services), By Methods (Solid Phase Synthesis, Microchip-based Oligonucleotide Synthesis, Chip-based DNA Synthesis, PCR-based Enzyme Synthesis), By Application (Therapeutics, Diagnostics, R&D activity, Other), By End User (Academic And Research Institutes, Biopharmaceutical Companies, Contract Research Organizations) - Industry Size, Growth, Share And Forecast To 2026
Gene synthesis offers solutions in synthetic biology for creating artificial genes in vitro with the help of solid phase DNA synthesis. Global gene synthesis market is expected to rise with a CAGR of 17.4% during the forecast year 2019-2026. Significant decrease in the cost of gene synthesis has promoted the demand in drug development, research activities, therapies, diagnostics etc. and has thus fuelled immense growth in the market.
Advent of revolutionary technologies such as CRISPR cas9 have brought a paradigmatic shift in the market by lowering the cost of gene synthesis and sequencing. According to the National Human Genome Research Institute (NHGRI), cost per raw mega base of DNA sequences has decreased from over $10,000 in 2001 to less than $1000 as of year 2017. Moreover, cost per genome has been estimated to lower from about $100 million to below $1000 during 2001-2017 respectively. This revolutionary change has boosted the demand for gene sequencing and synthesis. Furthermore, increased adoption of gene synthesis in personalized medicine and surging number of start-ups has also helped to drive the growth of the market.
Global gene synthesis market has been segmented based on products and services, applications, end user and method. Based on product and services, the market has been segmented into consumables, software and services. Furthermore, end users in the market cover academic and research institutes, biopharmaceutical companies, contract research organizations, etc. Biopharmaceutical companies dominate the market when it comes to end users owing to the rising demand of gene synthesis in drug discovery and development. Taking into consideration the methods, the market has been segmented into solid phase synthesis, chip-based DNA synthesis, PCR-based enzyme synthesis, microchip-based oligonucleotide synthesis.
Regional segmentation of the gene synthesis market includes North America, Europe, Asia Pacific and the rest of the world. North America dominates the market due to risen utilization of gene synthesis in the development of personalized medicine. For instance, as per the personalized medicine coalition, as of a 2018 survey, one in every four drugs is approved in the US by US Food and Drug Administration accounts for personalized medicine. Asia Pacific is expected to show rapid growth owing to the extensive genomics research and increasing number of gene synthesis based start-ups in the developing countries such as India, China and South Korea.
Major players across the market include Merck KGaA, Eurofins Genomics, Genscript Biotech Corp., Thermo Fisher Scientific Inc. (GeneArt), ATUM (DNA2.0 Inc.) and others. These companies are using various strategies such as collaboration, partnership, merger & acquisition, technology transfer and product launch. For instance, on 8th April 2019, Genscript Biotech Corp. a prime gene synthesis provider announced the launch of a public beta testing program for their precision mutant library services that is expected to be applied in industrial, chemical, drug development and synthetic biology. The service offers to determine the distribution of each codon resulting in a diverse library by utilizing advanced semiconductor-based oligonucleotide synthesis technology.
1. Preface
1.1. Report Scope and Description
1.1.1. Study Purpose
1.1.2. Target Audience
1.1.3. USP and Key Offerings
1.2. Research Scope
1.3. Research Methodology
1.3.1. Phase I – Secondary Research
1.3.2. Phase II – Primary Research
1.3.3. Phase III – Expert Panel Review
1.3.4. Approach Adopted
1.3.4.1. Top-Down Approach
1.3.4.2. Bottom-Up Approach
1.3.5. Assumptions
1.4. Market Segmentation
2. Executive Summary
2.1. Market Snapshot: Global Gene Synthesis Market
2.1.1. Global Gene Synthesis Market, by Product and Services, 2018 (US$ Mn)
2.1.2. Global Gene Synthesis Market, by Methods, 2018 (US$ Mn)
2.1.3. Global Gene Synthesis Market, by Applications, 2018 (US$ Mn)
2.1.4. Global Gene Synthesis Market, by End User, 2018 (US$ Mn)
2.1.5. Global Gene Synthesis Market, by Geography, 2018 (US$ Mn)
3. Market Dynamics
3.1. Introduction
3.2. Market Dynamics
3.2.1. Market Drivers
3.2.1.1. Surging number of startups in the market
3.2.1.2. Increasing adoption of gene synthesis in personalized medicine
3.2.1.3. Rising demand for synthetic genes
3.2.2. Market Restraints
3.2.2.1. Lack of availability of Skilled Professionals
3.2.3. Market Opportunities
3.2.3.1. Surge in research and development for next generation sequencing and genomics
3.2.3.2. Increasing growth in drug discoveries
3.2.4. Market Challenges
3.2.4.1. Minimizing cost related to technical complexities
3.2.4.2. Complex process for product approval and compliance
3.3. Attractive Investment Proposition, by Geography, 2018
3.4. Market share of Key Players, 2018
3.5. Top five findings and strategic analysis
4. Global Gene Synthesis Market, by Products and services
4.1. Overview
4.1.1. Global Gene Synthesis Market Value Share, by Product and Services, 2018 & 2026 (Value, %)
4.1.2. Global Gene Synthesis Market, by Product and Services, 2019-2026 (US$ Mn)
4.2. Consumables
4.2.1. Market Determinants (Drivers, Restraints, Challenges & Opportunity)
4.2.2. Global Gene Synthesis Market for Consumables, 2019-2026 (US$ Mn)
4.2.3. Global Gene Synthesis Market for Consumables, by Region 2019-2026 (US$ Mn)
4.3. Software’s
4.3.1. Market Determinants (Drivers, Restraints, Challenges & Opportunity)
4.3.2. Global Gene Synthesis Market for Software’s, 2019-2026 (US$ Mn)
4.3.3. Global Gene Synthesis Market for Software’s, by Region 2019-2026 (US$ Mn)
4.4. Services
4.4.1. Market Determinants (Drivers, Restraints, Challenges & Opportunity)
4.4.2. Global Gene Synthesis Market for Services, 2019-2026 (US$ Mn)
4.4.3. Global Gene Synthesis Market for Services, by Region 2019-2026 (US$ Mn)
5. Global Gene Synthesis Market, by Methods
5.1. Overview
5.1.1. Global Gene Synthesis Market Value Share, by Methods, 2018 & 2026 (Value, %)
5.1.2. Global Gene Synthesis Market, by Methods, 2019 – 2026 (US$ Mn)
5.2. Solid Phase Synthesis
5.2.1. Global Gene Synthesis Market for Solid Phase Synthesis, 2019 – 2026 (US$ Mn)
5.2.2. Global Gene Synthesis Market for Solid Phase Synthesis, by Region 2019-2026 (US$ Mn)
5.3. Microchip-based Oligonucleotide Synthesis
5.3.1. Global Gene Synthesis Market for Microchip-based Oligonucleotide Synthesis, 2019 – 2026 (US$ Mn)
5.3.2. Global Gene Synthesis Market for Solid Microchip-based Oligonucleotide Synthesis, by Region 2019-2026 (US$ Mn)
5.4. Chip-based DNA Synthesis
5.4.1. Global Gene Synthesis Market for Chip-based DNA Synthesis, 2019 – 2026 (US$ Mn)
5.4.2. Global Gene Synthesis Market for Chip-based DNA Synthesis, by Region 2019-2026 (US$ Mn)
5.5. PCR-based Enzyme Synthesis
5.5.1. Global Gene Synthesis Market for PCR-based Enzyme Synthesis, 2019 – 2026 (US$ Mn)
5.5.2. Global Gene Synthesis Market for PCR-based Enzyme Synthesis, by Region 2019-2026 (US$ Mn)
6. Global Gene Synthesis Market, by Application
6.1. Overview
6.1.1. Global Gene Synthesis Market Value Share, by Application, 2018 & 2026 (Value, %)
6.1.2. Global Gene Synthesis Market, by Application, 2019-2026 (US$ Mn)
6.2. Therapeutics
6.2.1. Market Determinants (Drivers, Restraints, Challenges & Opportunity)
6.2.2. Global Gene Synthesis Market for Therapeutics, 2019-2026 (US$ Mn)
6.2.3. Global Gene Synthesis Market for Therapeutics, by Region 2019-2026 (US$ Mn)
6.3. Diagnostics
6.3.1. Market Determinants (Drivers, Restraints, Challenges & Opportunity)
6.3.2. Global Gene Synthesis Market for Diagnostics, 2019-2026 (US$ Mn)
6.3.3. Global Gene Synthesis Market for Diagnostics, by Region 2019-2026 (US$ Mn)
6.4. R&D activity
6.4.1. Market Determinants (Drivers, Restraints, Challenges & Opportunity)
6.4.2. Global Gene Synthesis Market for R&D activity, 2019-2026 (US$ Mn)
6.4.3. Global Gene Synthesis Market for R&D activity, by Region 2019-2026 (US$ Mn)
6.5. Other Application
6.5.1. Market Determinants (Drivers, Restraints, Challenges & Opportunity)
6.5.2. Global Gene Synthesis Market for Other Application, 2019-2026 (US$ Mn)
6.5.3. Global Gene Synthesis Market for Other Application, by Region 2019-2026 (US$ Mn)
7. Global Gene Synthesis Market, by End User
7.1. Overview
7.1.1. Global Gene Synthesis Market Value Share, by End User, 2018 & 2026 (Value, %)
7.1.2. Global Gene Synthesis Market, by End User, 2019 – 2026 (US$ Mn)
7.2. Academic and Research Institutes
7.2.1. Global Gene Synthesis Market for Academic and Research Institutes, 2019 – 2026 (US$ Mn)
7.2.2. Global Gene Synthesis Market for Academic and Research Institutes, by Region 2019-2026 (US$ Mn)
7.3. Biopharmaceutical Companies
7.3.1. Global Gene Synthesis Market for Biopharmaceutical Companies, 2019 – 2026 (US$ Mn)
7.3.2. Global Gene Synthesis Market for Biopharmaceutical Companies, by Region 2019-2026 (US$ Mn)
7.4. Contract Research Organizations
7.4.1. Global Gene Synthesis Market for Contract Research Organizations, 2019 – 2026 (US$ Mn)
7.4.2. Global Gene Synthesis Market for Contract Research Organizations, by Region 2019-2026 (US$ Mn)
8. North America Gene Synthesis Market Analysis
8.1. Overview
8.1.1. North America Gene Synthesis Market, by Product and Services, 2019-2026 (US$ Mn)
8.1.2. North America Gene Synthesis Market, by Methods, 2019-2026 (US$ Mn)
8.1.3. North America Gene Synthesis Market, by Application, 2019-2026 (US$ Mn)
8.1.4. North America Gene Synthesis Market, by End User, 2019-2026 (US$ Mn)
8.1.5. North America Gene Synthesis Market, by Country, 2019-2026 (US$ Mn)
8.1.5.1. United States
8.1.5.1.1. United States Gene Synthesis Market 2019 – 2026 (US$ Mn)
8.1.5.2. Canada
8.1.5.2.1. Canada Gene Synthesis Market 2019 – 2026 (US$ Mn)
9. Europe Gene Synthesis Market Analysis
9.1. Overview
9.1.1. Europe Gene Synthesis Market, by Product and Services, 2019-2026 (US$ Mn)
9.1.2. Europe Gene Synthesis Market, by Methods, 2026 (US$ Mn)
9.1.3. Europe Gene Synthesis Market, by End User, 2026 (US$ Mn)
9.1.4. Europe Gene Synthesis Market, by Application, 2026 (US$ Mn)
9.1.5. Europe Gene Synthesis Market, by Country/Region, 2019-2026 (US$ Mn)
9.1.5.1. UK
9.1.5.1.1. UK Gene Synthesis Market 2019 – 2026 (US$ Mn)
9.1.5.2. Germany
9.1.5.2.1. Germany Gene Synthesis Market 2019 – 2026 (US$ Mn)
9.1.5.3. France
9.1.5.3.1. France Gene Synthesis Market 2019 – 2026 (US$ Mn)
9.1.5.4. Rest of Europe
9.1.5.4.1. Rest of Europe Gene Synthesis Market 2019 – 2026 (US$ Mn)
10. Asia Pacific Gene Synthesis Market Analysis
10.1. Overview
10.1.1. Asia Pacific Gene Synthesis Market, by Product and Services, 2019-2026 (US$ Mn)
10.1.2. Asia Pacific Gene Synthesis Market, by Methods, 2019-2026 (US$ Mn)
10.1.3. Asia Pacific Gene Synthesis Market, by End User, 2019-2026 (US$ Mn)
10.1.4. Asia Pacific Gene Synthesis Market, by Application, 2019-2026 (US$ Mn)
10.1.5. Asia Pacific Gene Synthesis Market, by Country/Region, 2019-2026 (US$ Mn)
10.1.5.1. China
10.1.5.1.1. China Gene Synthesis Market 2019 – 2026 (US$ Mn)
10.1.5.2. India
10.1.5.2.1. India Gene Synthesis Market 2019 – 2026 (US$ Mn)
10.1.5.3. Japan
10.1.5.3.1. Japan Gene Synthesis Market 2019 – 2026 (US$ Mn)
10.1.5.4. Rest of Asia Pacific
10.1.5.4.1. Rest of Asia Pacific Gene Synthesis Market 2019 – 2026 (US$ Mn)
11. Rest of the World Gene Synthesis Market Analysis
11.1. Overview
11.1.1. Rest of the World Gene Synthesis Market, by Product and Services, 2019-2026 (US$ Mn)
11.1.2. Rest of the World Gene Synthesis Market, by Methods, 2019-2026 (US$ Mn)
11.1.3. Asia Pacific Gene Synthesis Market, by Application, 2019-2026 (US$ Mn)
11.1.4. Rest of the World Gene Synthesis Market, by End User, 2019-2026 (US$ Mn)
11.1.5. Rest of the World Gene Synthesis Market, by Country/Region, 2019 – 2026 (US$ Mn)
11.1.5.1. Latin America
11.1.5.1.1. Latin America Gene Synthesis Market 2019 – 2026 (US$ Mn)
11.1.5.2. MENA
11.1.5.2.1. MENA Gene Synthesis Market 2019 – 2026 (US$ Mn)
12. Company Profiles
12.1. Merck KGaA
12.1.1. Company Overview
12.1.2. Product Portfolio
12.1.3. Key Strategies
12.1.4. Key Conclusion
12.2. Beijing SBS Genetech Co. Ltd
12.2.1. Company Overview
12.2.2. Product Portfolio
12.2.3. Key Strategies
12.2.4. Key Conclusion
12.3. Bio Basic Inc.
12.3.1. Company Overview
12.3.2. Product Portfolio
12.3.3. Key Strategies
12.3.4. Key Conclusion
12.4. ATUM (DNA2.0 Inc.)
12.4.1. Company Overview
12.4.2. Product Portfolio
12.4.3. Key Strategies
12.4.4. Key Conclusion
12.5. Genscript Biotech Corp.
12.5.1. Company Overview
12.5.2. Product Portfolio
12.5.3. Key Strategies
12.5.4. Key Conclusion
12.6. ATD Bio Ltd
12.6.1. Company Overview
12.6.2. Product Portfolio
12.6.3. Key Strategies
12.6.4. Key Conclusion
12.7. Eurofins Genomics
12.7.1. Company Overview
12.7.2. Product Portfolio
12.7.3. Key Strategies
12.7.4. Key Conclusion
12.8. Genewiz Inc.
12.8.1. Company Overview
12.8.2. Product Portfolio
12.8.3. Key Strategies
12.8.4. Key Conclusion
12.9. GeneArt (Thermo Fisher Scientific Inc.)
12.9.1. Company Overview
12.9.2. Product Portfolio
12.9.3. Key Strategies
12.9.4. Key Conclusion
12.10. OriGene Technologies Inc.
12.10.1. Company Overview
12.10.2. Product Portfolio
12.10.3. Key Strategies
12.10.4. Key Conclusion
1. Global Gene Synthesis Market, by Product and Services, 2019-2026 (US$ Mn)
2. Global Gene Synthesis Market for Consumables, by Region 2019-2026 (US$ Mn)
3. Global Gene Synthesis Market for Software’s, by Region 2019-2026 (US$ Mn)
4. Global Gene Synthesis Market for Services, by Region 2019-2026 (US$ Mn)
5. Global Gene Synthesis Market, by Methods, 2019-2026 (US$ Mn)
6. Global Gene Synthesis Market for Solid Phase Synthesis, by Region 2019-2026 (US$ Mn)
7. Global Gene Synthesis Market for Chip-based DNA Synthesis, by Region 2019-2026 (US$ Mn)
8. Global Gene Synthesis Market for PCR-based Enzyme Synthesis, by Region 2019-2026 (US$ Mn)
9. Global Gene Synthesis Market for Microchip-based Oligonucleotide Synthesis, by Region 2019-2026 (US$ Mn)
10. Global Gene Synthesis Market, by Applications, 2019-2026 (US$ Mn)
11. Global Gene Synthesis Market for Therapeutics, by Region 2019-2026 (US$ Mn)
12. Global Gene Synthesis Market for Diagnostics, by Region 2019-2026 (US$ Mn)
13. Global Gene Synthesis Market for R&D activities, by Region 2019-2026 (US$ Mn)
14. Global Gene Synthesis Market for other applications, by Region 2019-2026 (US$ Mn)
15. Global Gene Synthesis Market, by End User, 2019-2026 (US$ Mn)
16. Global Gene Synthesis Market for Academic and Research Institutes, by Region 2019-2026 (US$ Mn)
17. Global Gene Synthesis Market for Biopharmaceutical Companies, by Region 2019-2026 (US$ Mn)
18. Global Gene Synthesis Market for Contract Research Organizations, by Region 2019-2026 (US$ Mn)
19. Global Gene Synthesis Market, by Geography, 2019-2026 (US$ Mn)
20. North America Gene Synthesis Market, by Product and Services, 2019-2026 (US$ Mn)
21. North America Gene Synthesis Market, by Methods, 2019-2026 (US$ Mn)
22. North America Gene Synthesis Market, by End User, 2019-2026 (US$ Mn)
23. North America Gene Synthesis Market, by Country, 2019-2026 (US$ Mn)
24. Europe Gene Synthesis Market, by Product and Services, 2019-2026 (US$ Mn)
25. Europe Gene Synthesis Market, by Methods, 2019-2026 (US$ Mn)
26. Europe Gene Synthesis Market, by End User, 2019-2026 (US$ Mn)
27. Europe Gene Synthesis Market, by Country/Region, 2019-2026 (US$ Mn)
28. Asia Pacific Gene Synthesis Market, by Product and Services, 2019-2026 (US$ Mn)
29. Asia Pacific Gene Synthesis Market, by Methods, 2019-2026 (US$ Mn)
30. Asia Pacific Gene Synthesis Market, by End User, 2019-2026 (US$ Mn)
31. Asia Pacific Gene Synthesis Market, by Country/Region, 2019-2026 (US$ Mn)
32. Rest of the World Gene Synthesis Market, by Product and Services, 2019-2026 (US$ Mn)
33. Rest of the World Gene Synthesis Market, by Methods, 2019-2026 (US$ Mn)
34. Rest of the World Gene Synthesis Market, by End User, 2019-2026 (US$ Mn)
35. Rest of the World Gene Synthesis Market, by Country/Region, 2019 – 2026 (US$ Mn)
1. Global Gene Synthesis Market, by Product and Services, 2018 (US$ Mn)
2. Global Gene Synthesis Market, by Methods, 2018 (US$ Mn)
3. Global Gene Synthesis Market, by End User, 2018 (US$ Mn)
4. Global Gene Synthesis Market, by Application, 2018 (US$ Mn)
5. Global Gene Synthesis Market, by Geography, 2018 (US$ Mn)
6. Global Gene Synthesis Market Value Share, by Product and Services, 2018 & 2026 (Value, %)
7. Global Gene Synthesis Market for Consumables, 2019-2026 (US$ Mn)
8. Global Gene Synthesis Market for Software’s, 2019-2026 (US$ Mn)
9. Global Gene Synthesis Market for Services, 2019-2026 (US$ Mn)
10. Global Gene Synthesis Market Value Share, by Methods, 2018 & 2026 (Value, %)
11. Global Gene Synthesis Market for Solid Phase Synthesis, 2019-2026 (US$ Mn)
12. Global Gene Synthesis Market for Chip-based DNA Synthesis, 2019-2026 (US$ Mn)
13. Global Gene Synthesis Market for Microchip-based Oligonucleotide Synthesis, 2019-2026 (US$ Mn)
14. Global Gene Synthesis Market for PCR-based Enzyme Synthesis, 2019-2026 (US$ Mn)
15. Global Gene Synthesis Market Value Share, by Applications, 2018 & 2026 (Value, %)
16. Global Gene Synthesis Market for Therapeutics, 2019-2026 (US$ Mn)
17. Global Gene Synthesis Market for Diagnostics, 2019-2026 (US$ Mn)
18. Global Gene Synthesis Market for R&D activities, 2019-2026 (US$ Mn)
19. Global Gene Synthesis Market for Other Applications, 2019-2026 (US$ Mn)
20. Global Gene Synthesis Market Value Share, by End User, 2018 & 2026 (Value, %)
21. Global Gene Synthesis Market for Academic and Research Institutes, 2019-2026 (US$ Mn)
22. Global Gene Synthesis Market for Biopharmaceutical Companies, 2019-2026 (US$ Mn)
23. Global Gene Synthesis Market for Contract Research Organizations, 2019-2026 (US$ Mn)
24. United States Gene Synthesis Market 2019 – 2026 (US$ Mn)
25. Canada Gene Synthesis Market 2019 – 2026 (US$ Mn)
26. UK Gene Synthesis Market 2019 – 2026 (US$ Mn)
27. Germany Gene Synthesis Market 2019 – 2026 (US$ Mn)
28. France Gene Synthesis Market 2019 – 2026 (US$ Mn)
29. Rest of Europe Gene Synthesis Market 2019 – 2026 (US$ Mn)
30. China Gene Synthesis Market 2019 – 2026 (US$ Mn)
31. India Gene Synthesis Market 2019 – 2026 (US$ Mn)
32. Japan Gene Synthesis Market 2019 – 2026 (US$ Mn)
33. Rest of Asia Pacific Gene Synthesis Market 2019 – 2026 (US$ Mn)
34. Latin America Gene Synthesis Market 2019 – 2026 (US$ Mn)
35. MENA Gene Synthesis Market 2019 – 2026 (US$ Mn)
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